NFL 2025 Tickets: As the NFL gears up for the 2025 season, one team stands out uniquely and it’s not the reigning Super Bowl contenders. While many would expect the Philadelphia Eagles or Kansas City Chiefs to lead early betting projections. It’s the Buffalo Bills who currently find themselves favored in every single game on the schedule, according to the latest odds from BetMGM.
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This notable distinction places the Bills in a strong early position, even though it doesn’t necessarily mean they’re expected to dominate wire-to-wire. The Bills, who have won the AFC East five years in a row, have yet to reach the Super Bowl during that stretch. The franchise is still seeking its first-ever championship and hasn’t appeared in a Super Bowl in 32 years.
The hope in Buffalo is that this could finally be the season where that changes. Although the Bills are favoured in all 17 regular-season games, BetMGM has set their projected win total at 11.5, indicating a more measured expectation given the demanding nature of the NFL 2025 season. Betting odds indicate that the Bills are expected to be a top-tier team. They aren’t projected to finish the regular season undefeated a feat only accomplished twice in league history.
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Being favoured on paper doesn’t guarantee weekly success, especially in a league known for its parity and unpredictable outcomes. Buffalo holds the third-best odds to win the Super Bowl, behind only the Philadelphia Eagles and Baltimore Ravens. This placement reflects strong expectations but also underscores the fact that being favoured doesn’t equate to being the outright favourite.
Buffalo will still need to overcome several elite contenders to fulfil their championship aspirations. Interestingly, this isn’t the first time the Bills have entered a season as favourites in every matchup. They were in a similar position back in the 2022 season. That year, Buffalo finished with a 13-3 record, showing strong consistency throughout the regular season.
However, they posted a modest 8-7-1 record against the spread, highlighting the difference between winning games and exceeding betting expectations. As the 2025 season approaches, the Bills find themselves once again under the spotlight. With a strong roster, championship hopes, and a favourable betting outlook, Buffalo has the pieces in place to make a deep playoff run.
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NFL International Tickets: Buffalo Bills Enter 2025 Season as Favourites in Every Game
Here’s a breakdown of the Buffalo Bills’ game-by-game odds for the NFL 2025 regular season as provided by DraftKings Sportsbook. In a notable feat, the Bills are listed as favourites in all 17 games, further cementing their position as one of the top contenders in the league heading into the season.
According to DraftKings Sportsbook, the Buffalo Bills enter the NFL 2025 regular season as favourites in every game on their schedule. They kick off in Week 1 at home against the Baltimore Ravens, favoured by 1.5 points, before travelling to face the New York Jets in Week 2 as 8.5-point favourites. The Bills then host the Miami Dolphins and the New Orleans Saints in Weeks 3 and 4, with sizable spreads of 8.5 and 12.5 points, respectively.
and 12.5 points, respectively. In Week 5, Buffalo welcomes the New England Patriots as 8.5-point favourites. Followed by a road game against the Atlanta Falcons in Week 6, favoured by 5.5 points. After a bye in Week 7, they visit the Carolina Panthers in Week 8, favoured by 7 points. Week 9 brings a showdown at home with the Kansas City Chiefs, where the Bills hold a narrow 2.5-point advantage.
Buffalo then travels to Miami in Week 10 and hosts the Tampa Bay Buccaneers in Week 11, favoured by 5.5 points in both contests. The following weeks feature road trips to the Houston Texans (Week 12) and Pittsburgh Steelers (Week 13), with the Bills favoured by 3.5 and 4.5 points, respectively. In Week 14, Buffalo hosts the Cincinnati Bengals with a 5.5-point spread, then returns to New England in Week 15, again favoured by 5.5 points.

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The Bills visit the Cleveland Browns in Week 16, favoured by 8.5 points, before hosting the Philadelphia Eagles in Week 17, with a slim 1.5-point advantage. The regular season wraps up at home in Week 18 against the New York Jets, where Buffalo is favoured by 9.5 points. This consistent favouritism highlights the Bills as one of the league’s leading contenders heading into the new season.
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It’s not exactly a bold prediction, but based on past trends and the challenges in their 2025 schedule, the Buffalo Bills’ chances of going undefeated this season are about as slim as Tiger Woods winning a major championship this year. Despite being favored in all 17 games; the path ahead is anything but easy.
The Bills will face both of last year’s Super Bowl participants and enter a particularly difficult stretch beginning in Week 9. Over a six-game span, they’ll take on four playoff teams from last season, along with the Cincinnati Bengals. The same team that handed Buffalo a decisive loss at home in the 2022 AFC Divisional Round.
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This midseason gauntlet could be a major test for Buffalo’s resilience and playoff readiness. While an undefeated season appears highly unlikely, the Bills remain the frontrunners to claim another AFC East title. They’ve won the division five years running, and all signs point to a sixth. Buffalo boasts one of the most complete rosters in the NFL, led by reigning MVP quarterback Josh Allen.

He’ll be joined by dynamic running back James Cook and a revamped defence that has added serious firepower. On the defensive side, Buffalo made a splash in free agency by bringing in former Defensive Rookie of the Year Joey Bosa. They also strengthened their secondary by selecting cornerback Maxwell Hairston in the first round of the draft.
These additions could prove critical in helping the Bills navigate a tough slate of opponents and make another deep playoff push. While perfection may be out of reach, Buffalo is once again built to contend not just in their division, but for a potential Super Bowl run.
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