NFL 2025 Week 3 preview with key matchups, injury news, predictions, and betting insights. The third week of the 2025 NFL season is set to bring plenty of drama, as several highly anticipated games are on the slate. Fans will get to see clashes between unbeaten teams and injury shakeups affecting star quarterbacks. And struggling franchises looking to turn their seasons around before it’s too late. Among the marquee matchups.
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The Los Angeles Rams will travel to Philadelphia to face the Eagles. The Arizona Cardinals meet the San Francisco 49ers in another competition NFL 2025 featuring undefeated squads. Quarterback health looms as a major storyline this week. As several notable starters won’t be available. Cincinnati’s Joe Burrow is sidelined with a toe issue.
Minnesota rookie J.J. McCarthy will miss time because of an ankle injury, and Jets signal-caller Justin Fields has been ruled out due to a concussion. Other passers are dealing with more uncertain statuses. Including Brock Purdy of the 49ers, who is battling both a toe and shoulder problem, and Jayden Daniels of the Commanders, who is nursing a knee injury. Injuries create opportunities for backups to prove themselves in the NFL 2025.
NFL Dublin: Philly’s Ground Game & Defense
The week wraps up with a Monday night clash between the Detroit Lions and the Baltimore Ravens. Giving fans another heavyweight matchup in primetime. Analysts, reporters, and insiders have weighed in on each matchup, sharing locker-room insight, important statistics, bold predictions, fantasy football tips, and betting angles to help fans understand what to expect.
Expert score predictions and the Football Power Index offer deeper insight into how these games might play out. The Rams and Eagles face off in a battle of unbeatens, and it comes with fascinating subplots. The Eagles have started 2-0, becoming the first team since 2010 to open a season with two wins despite not throwing for a single passing touchdown.
Instead, their victories have leaned heavily on the ground attack and defensive playmaking. The Rams, meanwhile, have allowed just one touchdown through two games. Showing their defense is one of the toughest in the league so far. Rams head coach Sean McVay, despite Philadelphia’s lack of passing scores.
Offered high praise for Jalen Hurts, calling him a winner who can beat defenses with his throwing ability, mobility, and football intelligence. Philadelphia has plenty of confidence against the Rams’ defense, especially after how running back Saquon Barkley dominated Los Angeles in two meetings last season.
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NFL International: Barkley’s Run Dominance
Barkley piled up 460 rushing yards between a regular-season contest and a playoff matchup. Even punishing the Rams when they tried to load the box. Eagles left tackle Jordan Mailata expressed belief. That’s when the Rams commit extra defenders to stop the run; Philadelphia’s scheme can create big opportunities.
Hurts has scored a rushing touchdown in five consecutive games, tying the longest streak of his career, and oddsmakers expect the ground game to continue playing a huge role. One bold prediction is that Barkley could log at least 25 carries against a Rams defense that actually invites teams to run in NFL International.
Statistically, opponents are throwing far less than expected against Los Angeles. Preferring to pound the ball on the ground. For fantasy managers, Rams quarterback Matthew Stafford has shown excellent chemistry with his receivers. Puka Nacua and Davante Adams are already connecting on numerous deep throws this season. Philadelphia’s defensive front excels at stuffing the run.
Los Angeles may need to rely more heavily on Stafford’s arm to win. Bettors should also note that the Rams have covered the spread in six straight road games. Predictions for the outcome are split, with some siding with the Rams in a narrow win and others giving the edge to the Eagles by a small margin. Projections slightly favor Philadelphia, though the game is expected to be decided by just a few points.
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NFL London: Packers at Browns Prediction
Another intriguing contest features the Green Bay Packers against the Cleveland Browns. Green Bay’s rushing attack has been underwhelming so far, and now they face a Cleveland defense that has been the toughest in the league against the run. The Browns have surrendered just 92 rushing yards total across their first two outings.
Josh Jacobs, the Packers’ lead back, has managed to score in both games and extend his touchdown streak to ten consecutive contests dating back to last season, but he is only averaging 3.6 yards per attempt. Packers quarterback Jordan Love acknowledged that defenses are prioritizing stopping Jacobs, given the damage he did last year.
For Cleveland, the focus is on how to neutralize Green Bay’s disruptive pass rush, especially Micah Parsons, who has been a nightmare for opposing quarterbacks. Coaches are well aware that when Parsons is on the field, opposing passer ratings plummet dramatically. To limit his impact, the Browns are hoping to establish the run and avoid obvious passing situations.
Rookie running back Quinshon Judkins impressed in his debut, logging 20 snaps and 61 rushing yards. Joe Flacco praised his game-breaking potential, while Green Bay’s Karl Brooks is projected to exploit Cleveland’s shaky offensive line for a sack.
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NFL 2025 Games: Experts Favor Packers
From a fantasy perspective, Cleveland’s backfield is worth monitoring. As Jerome Ford led in snaps and targets last week, Judkins is quickly carving out a larger role. For bettors, Cleveland’s recent record as an underdog is concerning. The team has covered the spread in just seven of their past 22 games in that role.
Predictions lean heavily in Green Bay’s favor, with most experts picking the Packers by comfortable margins. Though the exact scores differ. Ball Power Index gives the Packers more than a 70% chance of victory, projecting an average margin of over eight points. Overall, Week 3 is packed with storylines: from quarterbacks trying to recover from injuries.
To rookies being tested, to teams either proving their hot starts are real or desperately trying to save their seasons. With key divisional battles, playoff implications even this early in the year, and plenty of uncertainty surrounding player health, fans can expect another thrilling weekend of NFL action.
By the time Monday night arrives and the Lions and Ravens square off under the lights, the standings could already look very different from how they appear today. The season is still young, but momentum swings in September often carry into the rest of the year, making every matchup in Week 3 a must-watch event.
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